Telomerase holoenzyme complex assembly

Across TCGA patient cohorts, RNA activity of the Telomerase holoenzyme complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU2F3, INTS5, and SNHG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomerase holoenzyme complex assembly activity versus POU2F3 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POU2F3 →	-0.539	-0.046	<.001	.001	3	4
OV	INTS5 →	+0.368	+0.103	.008	.003	3	3
OV	SNHG1 →	+0.623	+0.126	.001	.002	3	3
HNSC	CEP72 →	+0.646	+0.056	.004	.005	3	3
HNSC	DHCR7 →	+0.770	+0.050	.004	.001	3	3
LUAD	TMEM243 →	-0.603	-0.057	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905323 vs POU2F3 — LUAD

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