Semi-lunar valve development

Across TCGA patient cohorts, RNA activity of the Semi-lunar valve development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF17, PPM1F, and RSU1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semi-lunar valve development activity versus ARHGEF17 in CCRCC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGEF17 →	+0.398	+0.092	<.001	<.001	3	10
UCEC	PPM1F →	+0.365	+0.075	<.001	<.001	3	10
OV	RSU1 →	+0.428	+0.073	<.001	<.001	3	10
UCEC	TBC1D2B →	+0.304	+0.060	<.001	.001	3	10
BRCA	TMEM119 →	+0.758	+0.046	<.001	<.001	3	10
UCEC	FLNA →	+0.648	+0.055	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905314 vs ARHGEF17 — CCRCC

Explore this scatter interactively →