Semi-lunar valve development

Across TCGA patient cohorts, RNA activity of the Semi-lunar valve development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA20P1, CCN4, and SATB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semi-lunar valve development activity versus SPATA20P1 in OV (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPATA20P1 →	+0.636	+0.659	.005	<.001	3	5
BRCA	CCN4 →	+0.959	+0.660	<.001	<.001	3	4
BRCA	SATB2 →	+0.534	+0.691	<.001	.002	3	4
BRCA	SWAP70 →	+0.552	+0.725	<.001	.004	3	4
BRCA	PRICKLE1 →	+0.482	+0.550	.001	.003	3	4
BRCA	RCN3 →	+0.818	+0.725	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905314 vs SPATA20P1 — OV

Explore this scatter interactively →