Semi-lunar valve development

Across TCGA patient cohorts, RNA activity of the Semi-lunar valve development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AGR2, CDH11, and SLCO4C1_S16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semi-lunar valve development activity versus AGR2 in HNSC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AGR2 →	-0.840	-0.591	.003	.001	3	4
BRCA	CDH11 →	+0.703	+0.986	<.001	<.001	3	4
LSCC	SLCO4C1_S16 →	-1.122	-1.047	<.001	<.001	3	3
LUAD	TFF3 →	-1.853	-0.590	<.001	<.001	3	3
GBM	ISCA2 →	-0.233	-0.827	<.001	<.001	3	3
LSCC	RB1_S795 →	+0.963	+0.660	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905314 vs AGR2 — HNSC

Explore this scatter interactively →