Semi-lunar valve development

Across TCGA cell cohorts, RNA activity of the Semi-lunar valve development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX4, RPS11, and MZT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STX4 grouped by Semi-lunar valve development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	STX4 →	-0.742	-0.674	<.001	.001	3	5
BREAST	RPS11 →	+0.666	+0.512	.007	.009	3	5
KIDNEY	MZT1 →	+0.991	+1.292	.005	.002	3	5
PANCREAS	LRP8 →	+1.012	+0.779	.001	.006	3	4
PANCREAS	SEH1L →	+1.019	+0.661	.002	.009	3	4
OVARY	GOT2 →	+0.770	+0.854	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STX4 by Semi-lunar valve development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →