Semi-lunar valve development

Across TCGA cell cohorts, RNA activity of the Semi-lunar valve development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD81, TERT, and ITPR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semi-lunar valve development activity versus CD81 in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CD81 →	+1.132	+0.690	.003	.002	3	4
BLOOD_Lymphoma	TERT →	+1.644	+0.535	.003	.003	3	4
CNS	ITPR1 →	+1.334	+0.479	<.001	.008	3	4
CNS	NEURL1B →	-0.873	-0.364	.008	.005	3	4
LUNG_SCLC	ADAMTS7 →	-1.301	-0.605	.001	.006	3	4
LIVER	GK5 →	-0.725	-1.059	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905314 vs CD81 — BLOOD_Lymphoma

Explore this scatter interactively →