Regulation of modification of postsynaptic actin cytoskeleton

Across TCGA patient cohorts, RNA activity of the Regulation of modification of postsynaptic actin cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP1, BAIAP2, and SH3RF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of modification of postsynaptic actin cytoskeleton activity versus PARP1 in UCEC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PARP1 →	-0.785	-0.885	.004	.002	3	6
LSCC	BAIAP2 →	+1.095	+1.301	<.001	<.001	3	5
LSCC	SH3RF2 →	+0.890	+0.801	<.001	<.001	3	4
LSCC	SLFN11 →	-0.544	-0.658	.002	.006	3	4
LSCC	CRYBG2 →	+0.934	+0.687	<.001	<.001	3	4
LSCC	HNRNPA1P61 →	-0.321	-0.715	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905274 vs PARP1 — UCEC

Explore this scatter interactively →