Regulation of modification of postsynaptic actin cytoskeleton

Across TCGA cell cohorts, RNA activity of the Regulation of modification of postsynaptic actin cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY6G5C, BUD13, and NPAT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LY6G5C grouped by Regulation of modification of postsynaptic actin cytoskeleton-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LY6G5C →	+0.992	+1.406	<.001	<.001	3	4
BREAST	BUD13 →	+0.804	+1.211	<.001	<.001	3	4
BREAST	NPAT →	+0.583	+1.021	<.001	<.001	3	4
BREAST	EMSY →	+0.806	+1.090	<.001	<.001	3	4
BONE	ZSWIM9 →	+1.226	+1.511	<.001	.003	3	4
BREAST	PRRC2A →	+0.482	+0.789	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LY6G5C by Regulation of modification of postsynaptic actin cytoskeleton activity — CNS

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