Regulation of modification of postsynaptic actin cytoskeleton

Across TCGA cell cohorts, RNA activity of the Regulation of modification of postsynaptic actin cytoskeleton pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF2, LLGL2, and LAMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF2 grouped by Regulation of modification of postsynaptic actin cytoskeleton-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SRSF2 →	-0.416	-0.121	.001	.003	3	4
CNS	LLGL2 →	-0.361	-0.303	.001	.002	3	4
LARGE_INTESTINE	LAMP3 →	-0.156	-0.178	<.001	.002	3	4
LUNG_NSCLC_LUAD	RASA4B →	-0.080	-0.149	.001	<.001	3	4
LUNG_NSCLC_LUSC	EPB41 →	-0.171	-0.242	.003	.005	3	4
BLOOD_Lymphoma	CACNB4 →	-0.580	-0.275	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF2 by Regulation of modification of postsynaptic actin cytoskeleton activity — LARGE_INTESTINE

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