Positive regulation of chromatin organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromatin organization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1B, PWP1, and KRT18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBA1B grouped by Positive regulation of chromatin organization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TUBA1B →	-0.591	-0.151	.002	.008	3	5
OVARY	PWP1 →	-0.691	-0.227	<.001	.001	3	5
SKIN	KRT18 →	+1.760	+0.238	.004	.002	3	4
SKIN	XRRA1 →	-0.984	-0.236	<.001	.004	3	4
LIVER	ADAP1 →	+2.511	+0.269	<.001	.008	3	4
OVARY	PAK4 →	+0.693	+0.167	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBA1B by Positive regulation of chromatin organization activity — OVARY

Explore this box plot interactively →