Positive regulation of chromatin organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromatin organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPIPA8, THRAP3, and XAB2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromatin organization activity versus NPIPA8 in BLOOD_Leukemia (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NPIPA8 →	+4.631	+0.310	<.001	.001	3	1
BLOOD_Leukemia	THRAP3 →	+0.421	+0.218	.001	<.001	3	1
BLOOD_Leukemia	XAB2 →	+0.754	+0.184	<.001	.005	3	1
BLOOD_Leukemia	RSBN1 →	+0.495	+0.236	<.001	<.001	3	1
BLOOD_Leukemia	FAM83D →	+1.108	+0.240	.002	<.001	3	1
BLOOD_Leukemia	BABAM1 →	+0.700	+0.324	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905269 vs NPIPA8 — BLOOD_Leukemia

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