Positive regulation of chromatin organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSDMD, PPP2R5D, and PDLIM2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromatin organization activity versus GSDMD in BLOOD_Leukemia (Pearson r = -0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSDMD →	-1.128	-0.230	.004	.005	3	1
BLOOD_Leukemia	PPP2R5D →	+0.950	+0.224	.002	.001	3	1
BLOOD_Leukemia	PDLIM2 →	-1.565	-0.253	.002	.003	3	1
BLOOD_Leukemia	MPHOSPH10 →	-0.684	-0.228	.007	.003	3	1
BLOOD_Leukemia	THBS1 →	-1.945	-0.195	.003	.001	3	1
BLOOD_Leukemia	TSPAN3 →	+1.520	+0.312	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905269 vs GSDMD — BLOOD_Leukemia

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