Negative regulation of chromatin organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of chromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, SPIN1, and HNRNPR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chromatin organization activity versus SMC3 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC3 →	+0.287	+0.083	.003	<.001	3	7
GBM	SPIN1 →	+0.408	+0.099	<.001	<.001	3	7
GBM	HNRNPR →	+0.323	+0.090	<.001	<.001	3	7
GBM	SAE1 →	+0.455	+0.094	<.001	<.001	3	6
GBM	TNFAIP8L2 →	-0.771	-0.097	<.001	<.001	3	6
GBM	ADNP →	+0.316	+0.077	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905268 vs SMC3 — GBM

Explore this scatter interactively →