Negative regulation of chromatin organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of chromatin organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT2C, LRRC59, and KCNE2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chromatin organization activity versus KMT2C in LUNG_SCLC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KMT2C →	+0.804	+1.531	.002	<.001	3	6
URINARY_TRACT	LRRC59 →	-0.688	-0.335	.002	.003	3	4
URINARY_TRACT	KCNE2 →	+0.348	+0.277	.006	.005	3	4
LARGE_INTESTINE	MGA →	+0.683	+0.245	.008	.004	3	4
LUNG_SCLC	CIB1 →	-1.787	-1.220	<.001	.002	3	4
LUNG_SCLC	NOMO1 →	-1.006	-1.611	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905268 vs KMT2C — LUNG_SCLC

Explore this scatter interactively →