Regulation of modification of synaptic structure

Across TCGA patient cohorts, RNA activity of the Regulation of modification of synaptic structure pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24A, SERF2, and BAIAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of modification of synaptic structure activity versus SEC24A in CCRCC (Pearson r = -0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEC24A →	-0.282	-0.048	.003	.001	3	5
GBM	SERF2 →	-0.534	-0.050	<.001	.007	3	5
LSCC	BAIAP2 →	+0.571	+0.068	<.001	<.001	3	4
BRCA	TIAM1 →	+0.415	+0.034	<.001	<.001	3	4
BRCA	KLC2 →	+0.263	+0.028	.005	.003	3	4
CCRCC	RPS2 →	-0.228	-0.052	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905244 vs SEC24A — CCRCC

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