Regulation of modification of synaptic structure

Across TCGA patient cohorts, RNA activity of the Regulation of modification of synaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSME2P4, FKBP11, and VAX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of modification of synaptic structure activity versus PSME2P4 in LUAD (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PSME2P4 →	-0.250	-0.552	.008	<.001	3	5
LSCC	FKBP11 →	-0.519	-0.569	<.001	<.001	3	4
OV	VAX2 →	-0.610	-0.555	.005	.008	3	4
LUAD	CELP →	-0.048	-0.557	.005	<.001	3	4
OV	CNPY2 →	-0.450	-0.753	.005	.001	2	4
OV	RN7SL405P →	-0.211	-0.624	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905244 vs PSME2P4 — LUAD

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