Regulation of modification of synaptic structure

Across TCGA cell cohorts, RNA activity of the Regulation of modification of synaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF9, SOWAHB, and GPATCH11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of modification of synaptic structure activity versus SRSF9 in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SRSF9 →	+0.559	+0.239	.005	.001	3	4
LUNG_NSCLC_LUAD	SOWAHB →	+1.003	+0.334	.009	.008	3	3
KIDNEY	GPATCH11 →	+0.818	+0.370	.001	.002	3	3
OVARY	CNPPD1 →	+0.582	+0.758	.004	.009	3	3
BLOOD_Leukemia	FMNL1 →	+1.319	+0.183	<.001	<.001	2	4
BLOOD_Lymphoma	DENND1C →	+2.193	+0.333	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905244 vs SRSF9 — BLOOD_Lymphoma

Explore this scatter interactively →