Cellular response to L-glutamate

Across TCGA patient cohorts, RNA activity of the Cellular response to L-glutamate pathway is significantly associated with the RNA expression of multiple genes, with the LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMIGO1, BCL11A, and OGDHL, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to L-glutamate activity versus AMIGO1 in LUSC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	AMIGO1 →	+0.994	+0.075	<.001	<.001	3	25
STAD	BCL11A →	+1.434	+0.102	<.001	<.001	3	17
LGG	OGDHL →	+1.345	+0.070	<.001	<.001	3	16
UCEC	SQOR →	-0.602	-0.026	<.001	<.001	3	15
UCS	FOXO6 →	+1.560	+0.095	<.001	<.001	3	15
SARC	BAIAP2 →	+0.998	+0.060	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905232 vs AMIGO1 — LUSC

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