Cellular response to L-glutamate

Across TCGA patient cohorts, RNA activity of the Cellular response to L-glutamate pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAIAP2, ERO1A, and MMP14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to L-glutamate activity versus BAIAP2 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BAIAP2 →	+0.449	+0.058	<.001	.002	3	5
LUAD	ERO1A →	-0.507	-0.081	.004	<.001	3	5
BRCA	MMP14 →	-0.443	-0.068	<.001	<.001	3	5
BRCA	PCYT2 →	+0.292	+0.039	.001	.005	3	5
CCRCC	PLOD2 →	-0.741	-0.075	.001	<.001	3	5
UCEC	BCL11A_S432 →	+0.973	+0.122	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905232 vs BAIAP2 — LSCC

Explore this scatter interactively →