Cellular response to L-glutamate

Across TCGA patient cohorts, RNA activity of the Cellular response to L-glutamate pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS1, CCDC106, and PRKN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to L-glutamate activity versus ACSS1 in COAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACSS1 →	+0.637	+0.292	.006	.002	3	4
OV	CCDC106 →	+0.607	+0.608	.001	.008	3	4
LSCC	PRKN →	+0.360	+1.048	.001	<.001	3	4
COAD	NOL4L →	+0.736	+0.294	.006	.004	3	4
COAD	NCOA6 →	+0.896	+0.291	.004	.009	3	4
UCEC	RN7SKP124 →	+0.624	+0.371	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905232 vs ACSS1 — COAD

Explore this scatter interactively →