Cellular response to L-glutamate

Across TCGA cell cohorts, RNA activity of the Cellular response to L-glutamate pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JUNB, STYX, and CIC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JUNB grouped by Cellular response to L-glutamate-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	JUNB →	-2.485	-1.499	.003	.001	3	5
BREAST	STYX →	+0.555	+0.786	.005	.005	3	4
LIVER	CIC →	-0.981	-1.418	.004	.006	3	4
SKIN	GNG11 →	-1.777	-0.768	.005	.008	3	4
BREAST	GPR89A →	+0.564	+0.716	.003	.006	3	4
BLOOD_Leukemia	H3C3 →	+1.150	+0.979	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JUNB by Cellular response to L-glutamate activity — LIVER

Explore this box plot interactively →