Cellular response to L-glutamate

Across TCGA cell cohorts, RNA activity of the Cellular response to L-glutamate pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRSF5, PRPF6, and SMC3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to L-glutamate activity versus SRSF5 in LUNG_SCLC (Pearson r = 0.95).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SRSF5 →	+0.504	+0.571	.008	.009	2	1
LUNG_SCLC	PRPF6 →	+1.170	+0.571	.002	.009	2	1
LUNG_SCLC	SMC3 →	+0.280	+0.571	.008	.009	2	1
LUNG_SCLC	EFTUD2 →	+0.805	+0.571	<.001	.009	2	1
LUNG_SCLC	EML2 →	-1.270	-0.571	.003	.009	2	1
LUNG_SCLC	SNRPB2 →	+0.429	+0.571	.003	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905232 vs SRSF5 — LUNG_SCLC

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