Cellular response to L-glutamate

Across TCGA cell cohorts, RNA activity of the Cellular response to L-glutamate pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are LDN-193189, CI-1040, and VX-702, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LDN-193189 grouped by Cellular response to L-glutamate-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LDN-193189 →	-0.574	-0.550	.007	.001	2	1
LUNG_SCLC	CI-1040 →	-0.564	-0.477	.041	.007	1	1
LUNG_SCLC	VX-702 →	+0.479	+0.477	.034	.007	1	1
LUNG_SCLC	MCT4_1422 →	-0.270	-0.477	.002	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest associations by consensus.

LDN-193189 by Cellular response to L-glutamate activity — LUNG_SCLC

Explore this box plot interactively →