Positive regulation of cardiocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01697, PIM2, and DPEP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiocyte differentiation activity versus LINC01697 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01697 →	+0.431	+0.462	<.001	.005	3	4
HNSC	PIM2 →	+1.007	+0.551	.002	.001	3	4
HNSC	DPEP2 →	+0.377	+0.490	.005	.001	3	4
HNSC	IL16 →	+0.523	+0.482	<.001	.001	3	4
OV	C9orf139 →	+0.321	+0.618	.002	.002	3	4
HNSC	BTLA →	+0.655	+0.489	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905209 vs LINC01697 — LUAD

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