Positive regulation of cardiocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS2, APOBEC3B, and DNAJB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiocyte differentiation activity versus ACSS2 in BLOOD_Leukemia (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACSS2 →	-1.211	-0.301	.001	.007	3	4
BLOOD_Lymphoma	APOBEC3B →	-3.632	-0.193	<.001	.009	3	4
BLOOD_Myeloma	DNAJB1 →	+0.914	+0.418	.002	.001	3	4
BLOOD_Myeloma	TMEM168 →	+0.971	+0.516	.007	.003	3	3
LUNG_NSCLC_LUAD	INTS4 →	+0.526	+0.248	.001	.004	3	3
LUNG_NSCLC_LUAD	ADCK5 →	+1.016	+0.336	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905209 vs ACSS2 — BLOOD_Leukemia

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