Negative regulation of cardiocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MATN2, CROCC, and PTN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiocyte differentiation activity versus MATN2 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MATN2 →	+0.715	+0.062	.001	.001	3	7
UCEC	CROCC →	+0.565	+0.077	.001	<.001	3	6
BRCA	PTN →	+0.953	+0.046	<.001	<.001	3	6
CCRCC	SEC23B →	-0.286	-0.060	<.001	<.001	3	6
BRCA	SEPTIN11 →	+0.292	+0.049	<.001	<.001	3	6
HNSC	LAMB1 →	+0.468	+0.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905208 vs MATN2 — LSCC

Explore this scatter interactively →