Regulation of cardiocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTS, STK35, and ENC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTS grouped by Regulation of cardiocyte differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTS →	-0.695	-0.846	.003	.002	3	4
SKIN	STK35 →	+0.677	+0.434	<.001	.006	3	4
PANCREAS	ENC1 →	-1.349	-0.878	.006	.005	3	4
STOMACH	SHROOM1 →	-1.349	-0.230	.005	.009	1	6
BREAST	WDR7 →	-0.749	-0.568	<.001	.004	3	3
BLOOD_Leukemia	YARS1 →	+0.873	+1.009	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTS by Regulation of cardiocyte differentiation activity — OVARY

Explore this box plot interactively →