Regulation of cardiocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, GPRC5A, and ANXA8L1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiocyte differentiation activity versus EGFR in OESOPHAGUS (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EGFR →	+3.784	+1.729	<.001	<.001	3	9
BREAST	GPRC5A →	+2.280	+0.973	<.001	<.001	3	6
OESOPHAGUS	ANXA8L1 →	+3.535	+1.298	.003	.006	3	6
SOFT_TISSUE	HERPUD2 →	+0.876	+1.718	.009	<.001	3	5
OVARY	RIPK4 →	+2.396	+1.318	.002	<.001	3	5
OVARY	PAK4 →	+1.132	+1.265	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905207 vs EGFR — OESOPHAGUS

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