Manchette assembly

Across TCGA cell cohorts, RNA activity of the Manchette assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GP1BB, KIF11, and CEP95, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GP1BB grouped by Manchette assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GP1BB →	-1.415	-0.830	.001	.002	3	5
BLOOD_Leukemia	KIF11 →	+0.972	+0.789	.002	.004	3	4
OVARY	CEP95 →	-0.911	-1.025	<.001	.003	3	4
LUNG_NSCLC_LUAD	FBXL17 →	+0.552	+0.846	.003	.006	3	4
LARGE_INTESTINE	TLK2 →	-0.742	-1.297	<.001	<.001	2	5
LARGE_INTESTINE	FMNL2 →	-1.297	-1.196	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GP1BB by Manchette assembly activity — BLOOD_Leukemia

Explore this box plot interactively →