Manchette assembly

Across TCGA cell cohorts, RNA activity of the Manchette assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A2, SERPIND1, and CBX4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL6A2 grouped by Manchette assembly-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	COL6A2 →	-0.265	-1.379	.004	.002	3	3
LUNG_SCLC	SERPIND1 →	-0.171	-1.213	.002	<.001	3	3
URINARY_TRACT	CBX4 →	+0.155	+0.302	<.001	.002	3	3
LARGE_INTESTINE	RDH5 →	-0.127	-0.548	.001	.006	3	3
LARGE_INTESTINE	INPP5D →	+0.164	+1.084	<.001	.002	3	3
LUNG_NSCLC_LUSC	CAPNS2 →	+0.166	+0.340	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL6A2 by Manchette assembly activity — BLOOD_Myeloma

Explore this box plot interactively →