Positive regulation of double-strand break repair via homologous recombination

Across TCGA patient cohorts, RNA activity of the Positive regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLE, FANCA, and HELLS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair via homologous recombination activity versus POLE in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POLE →	+0.787	+0.612	<.001	<.001	3	6
GBM	FANCA →	+0.771	+0.602	<.001	<.001	3	6
GBM	HELLS →	+0.836	+0.583	.002	.002	2	6
HNSC	CIT →	+0.784	+0.290	<.001	.004	3	5
HNSC	ESCO2 →	+0.776	+0.254	<.001	<.001	3	5
UCEC	PIMREG →	+0.994	+0.253	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905168 vs POLE — GBM

Explore this scatter interactively →