Positive regulation of double-strand break repair via homologous recombination

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair via homologous recombination pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFDN4, TSEN2, and KAT5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFDN4 grouped by Positive regulation of double-strand break repair via homologous recombination-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PFDN4 →	+0.238	+0.203	.002	.004	3	5
OESOPHAGUS	TSEN2 →	+0.132	+0.160	.001	.003	3	5
LIVER	KAT5 →	-0.222	-0.216	<.001	<.001	3	5
OESOPHAGUS	ID2 →	+0.139	+0.133	.003	.007	3	5
UPPER_AERODIGESTIVE_TRACT	ATP8A1 →	-0.124	-0.210	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SECISBP2L →	+0.168	+0.181	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFDN4 by Positive regulation of double-strand break repair via homologous recombination activity — LUNG_SCLC

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