Positive regulation of double-strand break repair via homologous recombination

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF212, B4GALT1, and MOCS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF212 grouped by Positive regulation of double-strand break repair via homologous recombination-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF212 →	+0.672	+0.105	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	B4GALT1 →	+1.246	+0.207	.004	<.001	2	5
BONE	MOCS3 →	+0.737	+0.131	.007	.005	3	4
LUNG_NSCLC_LUSC	DDOST →	+0.626	+0.153	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	SNRPB2 →	+1.104	+0.252	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM43 →	+1.113	+0.191	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF212 by Positive regulation of double-strand break repair via homologous recombination activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →