Positive regulation of double-strand break repair via homologous recombination

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAK1BP1, ABR, and SLC43A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair via homologous recombination activity versus IRAK1BP1 in BONE (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IRAK1BP1 →	+1.067	+0.240	.001	.001	3	4
LUNG_SCLC	ABR →	+0.786	+0.117	.005	.003	3	4
BONE	SLC43A1 →	+1.544	+0.168	.001	.007	3	4
OESOPHAGUS	EIF3H →	+0.661	+0.245	.003	.001	2	5
OESOPHAGUS	COX6C →	+1.222	+0.214	.002	.006	3	4
SKIN	ZNF726 →	+1.384	+0.171	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905168 vs IRAK1BP1 — BONE

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