Regulation of membrane invagination

Across TCGA patient cohorts, RNA activity of the Regulation of membrane invagination pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALGPS1, LOXL2, and EMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane invagination activity versus RALGPS1 in LSCC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RALGPS1 →	-0.497	-0.124	.003	.001	3	5
PDAC	LOXL2 →	+0.778	+0.136	<.001	<.001	3	5
OV	EMP3 →	+0.593	+0.206	.006	<.001	3	5
PDAC	VSIG4 →	+0.782	+0.149	<.001	.005	3	5
PDAC	IGFL2 →	+1.273	+0.170	<.001	<.001	3	5
OV	CTSG →	+0.822	+0.246	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905153 vs RALGPS1 — LSCC

Explore this scatter interactively →