Regulation of membrane invagination

Across TCGA cell cohorts, RNA activity of the Regulation of membrane invagination pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, TMEM154, and TACSTD2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane invagination activity versus ITGA2 in URINARY_TRACT (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ITGA2 →	+3.737	+2.149	<.001	<.001	3	10
BREAST	TMEM154 →	+1.139	+1.132	<.001	<.001	3	7
PANCREAS	TACSTD2 →	+6.145	+1.535	<.001	.001	3	7
OESOPHAGUS	RWDD2A →	-0.825	-0.983	<.001	.003	3	7
LUNG_NSCLC_LUSC	GJB3 →	+4.880	+1.906	<.001	.008	3	6
URINARY_TRACT	ITGA6 →	+3.402	+2.265	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905153 vs ITGA2 — URINARY_TRACT

Explore this scatter interactively →