Regulation of voltage-gated sodium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of voltage-gated sodium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP4, LEMD2, and STK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of voltage-gated sodium channel activity activity versus GBP4 in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GBP4 →	-0.351	-0.051	.005	.001	3	4
LUAD	LEMD2 →	+0.215	+0.060	.003	.002	3	4
LSCC	STK4 →	-0.263	-0.049	<.001	<.001	3	4
LSCC	CORO1A →	-0.543	-0.082	<.001	<.001	3	4
PDAC	CDC23 →	-0.140	-0.051	.007	.009	3	4
BRCA	PIK3CD →	-0.391	-0.057	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905150 vs GBP4 — LSCC

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