Regulation of voltage-gated sodium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of voltage-gated sodium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLMAP_S235, SLMAP_S452, and RERE_S613, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of voltage-gated sodium channel activity activity versus SLMAP_S235 in BRCA (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLMAP_S235 →	+0.623	+0.413	<.001	<.001	3	4
PDAC	SLMAP_S452 →	+0.691	+0.498	<.001	.004	2	5
UCEC	RERE_S613 →	-0.422	-0.814	<.001	<.001	3	3
GBM	SNRPD3 →	-0.217	-0.721	<.001	<.001	3	3
HNSC	SRRM1_T793 →	-0.737	-1.332	<.001	<.001	3	3
GBM	CAMSAP3_S554 →	+0.888	+0.874	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905150 vs SLMAP_S235 — BRCA

Explore this scatter interactively →