Regulation of voltage-gated sodium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of voltage-gated sodium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1H, SLC16A14, and PI3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1H grouped by Regulation of voltage-gated sodium channel activity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPM1H →	-1.646	-1.842	.007	<.001	3	4
PANCREAS	SLC16A14 →	-1.981	-1.590	.005	.002	3	4
BREAST	PI3 →	+2.424	+0.719	<.001	.001	3	4
BREAST	FOXF2 →	+1.826	+0.804	<.001	.004	3	4
OESOPHAGUS	ZNF500 →	+0.485	+1.464	.006	<.001	3	3
OESOPHAGUS	DIS3L →	-0.888	-1.214	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1H by Regulation of voltage-gated sodium channel activity activity — LARGE_INTESTINE

Explore this box plot interactively →