Response to acetylcholine

Across TCGA patient cohorts, RNA activity of the Response to acetylcholine pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR223HG, PIK3CG, and ITGAX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acetylcholine activity versus MIR223HG in PDAC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MIR223HG →	+1.108	+0.219	<.001	<.001	3	8
OV	PIK3CG →	+0.586	+0.149	.005	.001	3	6
OV	ITGAX →	+1.103	+0.166	<.001	<.001	3	6
GBM	SHISAL1 →	+0.844	+0.559	<.001	.001	3	6
OV	IL10RA →	+1.052	+0.166	.002	<.001	3	5
PDAC	CSF3R →	+1.002	+0.221	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905144 vs MIR223HG — PDAC

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