Positive regulation of vascular associated smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, HSPG2, and FERMT2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell differentiation activity versus CYGB in OV (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYGB →	+0.707	+0.045	.004	.009	3	9
OV	HSPG2 →	+0.603	+0.073	<.001	<.001	3	9
UCEC	FERMT2 →	+0.753	+0.101	<.001	<.001	3	9
UCEC	MYLK →	+0.713	+0.084	<.001	.001	2	10
UCEC	ILK →	+0.470	+0.106	<.001	<.001	3	9
HNSC	LAMC1 →	+0.468	+0.057	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905065 vs CYGB — OV

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