Positive regulation of vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPS2, FYCO1, and CDS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPS2 grouped by Positive regulation of vascular associated smooth muscle cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CAPS2 →	-1.166	-1.125	<.001	<.001	3	4
BLOOD_Lymphoma	FYCO1 →	-1.010	-2.187	.002	<.001	3	4
BREAST	CDS1 →	+0.978	+0.778	.007	.005	3	4
BREAST	ZXDC →	+0.529	+0.539	.001	.009	3	4
OVARY	SLC9B2 →	-0.926	-0.770	.001	.007	3	4
OVARY	XPC →	-0.837	-1.180	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPS2 by Positive regulation of vascular associated smooth muscle cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →