Positive regulation of vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC26, TAS2R42, and C1QTNF9B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC26 grouped by Positive regulation of vascular associated smooth muscle cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TTC26 →	-0.263	-1.244	.001	<.001	3	2
LUNG_NSCLC_LUAD	TAS2R42 →	+0.300	+0.368	.003	.001	3	2
LUNG_NSCLC_LUAD	C1QTNF9B →	+0.386	+0.435	.001	<.001	3	2
LUNG_NSCLC_LUAD	DPM1 →	-0.137	-0.368	.006	.001	3	2
LUNG_SCLC	RCE1 →	-0.243	-0.297	<.001	.003	3	2
BREAST	SGK2 →	+0.341	+0.277	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC26 by Positive regulation of vascular associated smooth muscle cell differentiation activity — SKIN

Explore this box plot interactively →