Positive regulation of vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM3D, TSNAXIP1, and ISCA1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell differentiation activity versus FAM3D in LUNG_SCLC (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM3D →	-0.072	-0.200	.004	.009	3	2
BREAST	TSNAXIP1 →	+0.565	+0.275	<.001	.007	3	2
LUNG_NSCLC_LUAD	ISCA1 →	+1.669	+0.453	.007	<.001	3	2
LUNG_NSCLC_LUAD	HRCT1 →	-1.665	-0.375	.009	.001	3	2
BREAST	BBS9 →	+0.875	+0.260	.001	.003	3	2
BREAST	RGS10 →	-1.501	-0.276	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905065 vs FAM3D — LUNG_SCLC

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