Negative regulation of vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TESMIN, H2AW, and SPHK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TESMIN grouped by Negative regulation of vascular associated smooth muscle cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TESMIN →	-2.381	-1.916	<.001	<.001	3	3
SOFT_TISSUE	H2AW →	-1.860	-1.061	.001	.001	3	3
URINARY_TRACT	SPHK1 →	+2.793	+0.522	.003	.003	2	4
SKIN	MAB21L3 →	-0.163	-0.300	.003	.001	3	3
LUNG_NSCLC_LUAD	NEU3 →	+0.541	+0.433	.001	.009	2	4
LUNG_NSCLC_LUAD	RGMB →	+1.094	+0.541	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TESMIN by Negative regulation of vascular associated smooth muscle cell differentiation activity — BONE

Explore this box plot interactively →