Regulation of vascular associated smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PCPG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFB, NFATC2, and PDGFRB, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular associated smooth muscle cell differentiation activity versus PDGFB in PCPG (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	PDGFB →	+1.161	+0.044	<.001	<.001	3	26
UCS	NFATC2 →	+1.010	+0.041	<.001	.001	2	27
PCPG	PDGFRB →	+1.220	+0.046	<.001	<.001	3	26
ESCA	GIMAP6 →	+1.183	+0.050	<.001	<.001	3	26
TGCT	GIMAP5 →	+0.886	+0.041	<.001	<.001	3	26
ESCA	STAB1 →	+1.238	+0.054	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905063 vs PDGFB — PCPG

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