Autophagosome organization

Across TCGA patient cohorts, RNA activity of the Autophagosome organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF133, RP9, and C20orf27, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome organization activity versus ZNF133 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF133 →	-0.341	-0.168	<.001	<.001	3	5
BRCA	RP9 →	-0.463	-0.187	.001	<.001	3	5
BRCA	C20orf27 →	-0.577	-0.176	.005	<.001	3	4
CCRCC	SV2A →	-0.337	-0.151	.003	.006	3	4
BRCA	PRRX2 →	-1.060	-0.181	<.001	<.001	3	4
BRCA	NT5DC2 →	-0.833	-0.193	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905037 vs ZNF133 — BRCA

Explore this scatter interactively →