Regulation of antifungal innate immune response

Across TCGA patient cohorts, RNA activity of the Regulation of antifungal innate immune response pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TSHZ1_T852, ARHGEF10, and VCL_S795, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antifungal innate immune response activity versus TSHZ1_T852 in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TSHZ1_T852 →	-0.811	-0.054	<.001	.002	3	6
UCEC	ARHGEF10 →	-0.287	-0.047	.005	.007	3	6
OV	VCL_S795 →	-0.750	-0.067	<.001	<.001	3	5
CCRCC	CLEC3B →	-0.617	-0.047	.001	.002	3	5
CCRCC	CLINT1 →	+0.178	+0.041	<.001	.007	3	5
CCRCC	COL5A1 →	-0.614	-0.048	.005	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905034 vs TSHZ1_T852 — OV

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