Regulation of membrane repolarization during cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane repolarization during cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1orf226_S223, EPS8L3_S445, and PCSK1N, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization during cardiac muscle cell action potential activity versus C1orf226_S223 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C1orf226_S223 →	+0.534	+0.059	.001	.001	3	4
LUAD	EPS8L3_S445 →	+2.624	+0.148	.002	<.001	3	4
LUAD	PCSK1N →	-1.187	-0.083	<.001	.001	3	4
PDAC	FAM83H_S870 →	-0.581	-0.057	.003	.007	2	5
UCEC	SFN →	-1.092	-0.109	<.001	<.001	3	4
UCEC	ELF3 →	+0.491	+0.126	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905031 vs C1orf226_S223 — LUAD

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