Regulation of membrane repolarization during ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane repolarization during ventricular cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCEA3, YY1AP1_S724, and ZNF687, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization during ventricular cardiac muscle cell action potential activity versus TCEA3 in CCRCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TCEA3 →	+0.546	+0.071	<.001	<.001	3	6
LSCC	YY1AP1_S724 →	+0.466	+0.071	<.001	<.001	3	5
LSCC	ZNF687 →	+0.297	+0.068	<.001	<.001	3	5
BRCA	C1orf226_S198 →	+0.899	+0.084	<.001	<.001	3	5
LSCC	ERBB3 →	+0.229	+0.056	.002	.001	3	5
LSCC	ZBTB7B →	+0.323	+0.091	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905024 vs TCEA3 — CCRCC

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